Mykietyn composes on commissions from many festivals and institutions, amongst others the Warsaw Autumn Festival, the Polish Radio, the Wielki Theatre – National Opera, the National Audiovisual Institute, from bands such as the Belcea Quartet, de Ereprijs, Icebreaker and the Kronos Quartet, and performers, including Elżbieta Chojnacka, Jerzy Artysz, Andrzej Bauer, Maciej Grzybowski, Ewa Pobłocka, Jacek Laszczkowski, Jadwiga Rappé, as well as conductors – amongst others Jean-Paul Dessy, Jacek Kaspszyk, Jerzy Maksymiuk, Diego Masson, Wojciech Michniewski and Marek Moś. He also writes music for theatre, cooperating with, amongst others, Piotr Cieślak, Grzegorz Jarzyna and Andrzej Woron. For many years he collaborated with Krzysztof Warlikowski, who directed his opera An Ignoramus and a Madman (2000). In 1997-2001, he was the music director at the Studio Theatre in Warsaw, and since 2008 he has been conducting the music scene at the Nowy Theatre. In 2011, the album Mykietyn: Teatr was released. It contains pieces from Warlikowski's performances selected by the composer himself.
In 2015, the premiere of Andrzej Chyra's The Magic Mountain with music by Mykietyn, libretto by Małgorzata Sikorska-Miszczuk and stage design by Mirosław Bałka took place at the Malta Festival in Poznań. Jacek Hawryluk wrote about Mykietyn's music in Gazeta Wyborcza:
Mykietyn's world of sound is very tempting: it refers to intelligent, non-academic electronics (more of the 90s than the latest productions), pop songs, sound effects of modern technology. But this is only the first impression.
Going further, we will hear echoes of the early music (deformed polyphony), fascination with microtonality, small gestures from which the score is woven. All of this overlaps with another aspect that the composer has already applied in the ‘Flute Concerto’ – the relativisation of time, ‘accelerating’ and ‘slowing it down’ (each subsequent quarter note does not last the same amount of time as the previous one, but is, for example, a bit slower). As a result, the sound is blurred, foreground and background are overlapped and mixed, and an impression of intermittent idleness and uncertainty occurs. Listening to the ‘Magic Mountain’ is like floating amidst sounds. It is a cool, mathematical score warmed up by human emotions.
Mykietyn composes film music as well. He wrote music to, amongst others, Małgorzata Szumowska's Stranger, 33 Scenes from Life and In the Name of..., Andrzej Wajda's Sweet Rush and Wałęsa: Man of Hope, as well as Essential Killing and 11 Minutes by Jerzy Skolimowski. For the music to Szumowska's Father, he was awarded the Prix France Musique Sacem. Other achievements of Paweł Mykietyn in the field of film music include the Polish Film Award ‘Eagle’, an award in the Main Competition of the Gdynia Film Festival and the Fryderyk Award in the Composer of the Year category.